The cast of the film includes Mohanlal, Shivarajkumar, Jackie Shroff, Mithun Chakraborty, Vidya Balan, SJ Suryah, Suraj Venjaramoodu, Ramya Krishnan, Mirnaa Menon, Yogi Babu, Jatin Sarna, Tamizh, Ramachandran Durairaj, Jaffer Saadiq, Bagavathi Perumal, Meghana Raj Sarja, and Bjorn Surrao, among others.

Anirudh has composed music for the upcoming film. The complete soundtrack for the film was released alongside a rave event, held in Chennai recently.

The crew of Jailer 2 also includes cinematographer Vijay Kartik Kannan, editor R Nirmal, art director Drk Kiran, and action choreographer Chethan D’Souza.  Kalanithi Maran has produced the upcoming film under his Sun Pictures banner.